INVIVO EVIDENCE FOR AN INHIBITORY GLUTAMATERGIC CONTROL OF SEROTONIN RELEASE IN THE CAT CAUDATE-NUCLEUS - INVOLVEMENT OF GABA NEURONS

被引:68
作者
BECQUET, D [1 ]
FAUDON, M [1 ]
HERY, F [1 ]
机构
[1] FAC MED NORD, NEUROENDOCRINOL EXPTL LAB,CNRS,INSERM,U297, BD PIERRE DRAMARD, F-13326 MARSEILLE 15, FRANCE
关键词
Cat; Caudate nucleus; l-Glutamic acid; N-Methoxy-d-aspartic acid; [!sup]3[!/sup]H]Serotonin release; in vivo; γ-Aminobutyric acid;
D O I
10.1016/0006-8993(90)90063-H
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The local effect of l-glutamic acid (5 × 10-5 M) on the release of [3H]serotonin continuously synthesized from [3H]tryptophan was examined in the caudate nucleus of 'encéphale isolé' unanaesthetized cats implanted with push-pull cannula. l-Glutamic acid (5 × 10-5 M) decreased [3H]serotonin release from nerve terminals of the dorsalis raphe-striatal serotonergic neurons. The effect was antagonized by 2-amino-6-triflurromethoxybenzothiazole (PK 26124) (10-6 M), an antagonist of glutamatergic transmission. This effect was mimicked by N-methoxy-d-aspartate acid NMDA (5 × 10-5 M) and prevented by dl-2-phosphono-valeric acid (APV) (5 × 10-5 M), indicating that l-glutamic acid decreased serotonin release via a N-methoxy-d-aspartate type receptor. The superfusion of serotonergic nerve terminals in the caudate nucleus with tetrodotoxin prevented the inhibitory l-glutamic acid-induced effect on serotonin release. Furthermore, l-glutamic acid-induced inhibition of [3H]serotonin release was antagonized by bicuculline (5 × 10-5 M). These data suggest that the glutamatergic receptors involved were not located directly on serotonin nerve terminals. The inhibitory control exerted by l-glutamic acid on serotonergic transmission could involve γ-aminobutyric acid interneurons. Since no reduction of spontaneous [3H]serotonin release was observed in the presence of bicuculline, GABAergic neurons appeared to exert a phasic influence on serotonin release. Indirect inhibitory presynaptic control on serotonin release mediated by corticostriatal glutamatergic fibers is discussed in light of previous findings. © 1990.
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页码:82 / 88
页数:7
相关论文
共 37 条
[1]   INVIVO EVIDENCE FOR ACETYLCHOLINE CONTROL OF SEROTONIN RELEASE IN THE CAT CAUDATE-NUCLEUS - INFLUENCE OF HALOTHANE ANESTHESIA [J].
BECQUET, D ;
FAUDON, M ;
HERY, F .
NEUROSCIENCE, 1988, 27 (03) :819-826
[2]   2-AMINO-6-TRIFLUOROMETHOXY BENZOTHIAZOLE, A POSSIBLE ANTAGONIST OF EXCITATORY AMINO-ACID NEUROTRANSMISSION .2. BIOCHEMICAL-PROPERTIES [J].
BENAVIDES, J ;
CAMELIN, JC ;
MITRANI, N ;
FLAMAND, F ;
UZAN, A ;
LEGRAND, JJ ;
GUEREMY, C ;
LEFUR, G .
NEUROPHARMACOLOGY, 1985, 24 (11) :1085-1092
[3]   DOPAMINE MODULATION OF ACETYLCHOLINE-RELEASE FROM THE GUINEA-PIG BRAIN [J].
BIANCHI, C ;
TANGANELLI, S ;
BEANI, L .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 58 (03) :235-246
[4]  
BOLAM JP, 1984, FUNCTIONS BASAL GANG, P30
[5]   INVIVO PRESYNAPTIC CONTROL OF DOPAMINE RELEASE IN THE CAT CAUDATE-NUCLEUS .2. FACILITATORY OR INHIBITORY INFLUENCE OF L-GLUTAMATE [J].
CHERAMY, A ;
ROMO, R ;
GODEHEU, G ;
BARUCH, P ;
GLOWINSKI, J .
NEUROSCIENCE, 1986, 19 (04) :1081-1090
[6]   PRESYNAPTIC REGULATION OF NEUROTRANSMITTER RELEASE IN THE BRAIN - FACTS AND HYPOTHESIS [J].
CHESSELET, MF .
NEUROSCIENCE, 1984, 12 (02) :347-375
[7]   ANATOMICAL ORGANIZATION OF EXCITATORY AMINO-ACID RECEPTORS AND THEIR PATHWAYS [J].
COTMAN, CW ;
MONAGHAN, DT ;
OTTERSEN, OP ;
STORMMATHISEN, J .
TRENDS IN NEUROSCIENCES, 1987, 10 (07) :273-280
[8]  
COTMAN CW, 1987, EXCITATORY AMINO ACI, P325
[9]  
DAVIES J, 1988, EXCITATORY AMINO ACI, P47
[10]   DORSAL AND MEDIAL RAPHE PROJECTIONS TO SUBSTANTIA NIGRA IN RAT - ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND BEHAVIORAL OBSERVATIONS [J].
DRAY, A ;
DAVIES, J ;
OAKLEY, NR ;
TONGROACH, P ;
VELLUCCI, S .
BRAIN RESEARCH, 1978, 151 (03) :431-442