PHAGOCYTOSIS-INDUCED RELEASE OF ARACHIDONIC-ACID FROM HUMAN-NEUTROPHILS

被引：75

作者：

WAITE, M

DECHATELET, LR

KING, L

SHIRLEY, PS

机构：

[1] Department of Biochemistry, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 03期

关键词：

D O I：

10.1016/0006-291X(79)91924-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The phospholipids of human neutrophils were labeled with [3H] arachidonic acid and [14C] palmitic acid. Phagocytosis of opsonized zymosan resulted in rapid release of free arachidonic acid but not of palmitic acid. Arachidonic acid was not released when the cells were exposed to unopsonized zymosan, zymosan-activated serum, or phorbol myristate acetate. These observations suggest that phagocytosis of opsonized zymosan results in the activation of a phospholipase A2. © 1979.

引用

页码：984 / 992

页数：9

共 18 条

[1]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[2] ARACHIDONIC-ACID METABOLISM IN POLYMORPHONUCLEAR LEUKOCYTES .3. EFFECTS OF IONOPHORE-A23187 [J].