CHANNELING BIAS IN THE INTERPRETATION OF DRUG EFFECTS

被引：194

作者：

PETRI, H

URQUHART, J

机构：

[1] Department of Epidemiology, University of Limburg, Maastricht

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1002/sim.4780100409

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Channeling is a form of allocation bias, where drugs with similar therapeutic indications are prescribed to groups of patients with prognostic differences. Claimed advantages of a new drug may channel it to patients with special pre-existing morbidity, with the consequence that disease states can be incorrectly attributed to use of the drug. For the study of adverse drug reactions, large databases supply information on comedication and morbidity of patients. For diseases with a stepped-care approach, the drug history of patients, as available from some databases, can show channeling of drugs to patients with markers of relatively severe disease.

引用

页码：577 / 581

页数：5

共 11 条

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