TRIGLYCERIDE-INTEGRATED CONCENTRATION - RELATIONSHIP TO INSULIN-INTEGRATED CONCENTRATION

The relationship between plasma insulin and plasma triglyceride concentrations in response to diet alterations was studied in eight healthy adult male subjects. Four isocaloric formula diets, providing either 45% or 65% of total energy from carbohydrate and, using either sucrose or corn syrup as the carbohydrate source, were ingested for 10 days in a Latin Square sequence. Plasma triglyceride and insulin responses to diet alterations were assessed in blood samples after overnight fast and in samples obtained by a 24-hr continuous withdrawal technique, the mean concentrations of plasma insulin and plasma triglyceride during the 24-hr period of study were designated as the insulin-integrated concentration and triglyceride-integrated concentration respectively. Mean insulin integrated concentrations were 45% to 57% higher and mean triglyceride integrated concentrations 19% to 27% lower during ingestion of analogous diets containing sucrose. Increases in the percentage of total energy supplied as carbohydrate did not significantly change the insulin integrated concentration. Seven of the eight subjects had higher insulin-integrated concentrations associated with lower triglyceride-integrated concentrations during the four diet periods (r ranged from -.536 to -.777), while one subject had a positive correlation (+.324). There was a statistically significant (p < .01) inverse relationship between the mean insulin- and triglyceride-integrated concentrations during the four diet periods. © 1979.