TRIPLEX FORMATION BY AN OLIGONUCLEOTIDE CONTAINING N(4)-(3-ACETAMIDOPROPYL)CYTOSINE

被引：50

作者：

HUANG, CY ^{[1
]}

CUSHMAN, CD ^{[1
]}

MILLER, PS ^{[1
]}

机构：

[1] JOHNS HOPKINS UNIV, SCH HYG & PUBL HLTH, DEPT BIOCHEM, BALTIMORE, MD 21205 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 19期

关键词：

D O I：

10.1021/jo00071a010

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Triplex formation has been observed between an oligodeoxyribonucleotide duplex and an oligodeoxyribopyrimidine which contains N4-(3-acetamidopropyl)cytosine, a novel base analog which selectively interacts with a C-G base pair of the target duplex.

引用

页码：5048 / 5049

页数：2

共 18 条

[1] NMR-STUDIES OF DNA (R+)N.(Y-)N.(Y+)N TRIPLE HELICES IN SOLUTION - IMINO AND AMINO PROTON MARKERS OF T.A.T AND C.G.C+ BASE-TRIPLE FORMATION [J].

DELOSSANTOS, C ;

ROSEN, M ;

PATEL, D .

BIOCHEMISTRY, 1989, 28 (18) :7282-7289

[2] SEQUENCE-SPECIFIC RECOGNITION OF THE MAJOR GROOVE OF DNA BY OLIGODEOXYNUCLEOTIDES VIA TRIPLE HELIX FORMATION - FOOTPRINTING STUDIES [J].

FRANCOIS, JC ;

SAISONBEHMOARAS, T ;

HELENE, C .

NUCLEIC ACIDS RESEARCH, 1988, 16 (24) :11431-11440

[3]

GRIFFIN L, SCIENCE, V245, P967

[4] RECOGNITION OF ALL 4 BASE-PAIRS OF DOUBLE-HELICAL DNA BY TRIPLE-HELIX FORMATION - DESIGN OF NONNATURAL DEOXYRIBONUCLEOSIDES FOR PYRIMIDINE.PURINE BASE PAIR BINDING [J].

GRIFFIN, LC ;

KIESSLING, LL ;

BEAL, PA ;

GILLESPIE, P ;

DERVAN, PB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (21) :7976-7982

[5] FLANKING SEQUENCE EFFECTS WITHIN THE PYRIMIDINE TRIPLE-HELIX MOTIF CHARACTERIZED BY AFFINITY CLEAVING [J].

KIESSLING, LL ;

GRIFFIN, LC ;

DERVAN, PB .

BIOCHEMISTRY, 1992, 31 (10) :2829-2834

[6] SEQUENCE-TARGETED CHEMICAL MODIFICATIONS OF NUCLEIC-ACIDS BY COMPLEMENTARY OLIGONUCLEOTIDES COVALENTLY LINKED TO PORPHYRINS [J].

LEDOAN, T ;

PERROUAULT, L ;

CHASSIGNOL, M ;

THUONG, NT ;

HELENE, C .

NUCLEIC ACIDS RESEARCH, 1987, 15 (21) :8643-8659

[7] STRUCTURE AND STABILITY OF X.G.C MISMATCHES IN THE 3RD STRAND OF INTRAMOLECULAR TRIPLEXES [J].

MACAYA, RF ;

GILBERT, DE ;

MALEK, S ;

SINSHEIMER, JS ;

FEIGON, J .

SCIENCE, 1991, 254 (5029) :270-274

[8] SEQUENCE SPECIFICITY IN TRIPLE-HELIX FORMATION - EXPERIMENTAL AND THEORETICAL-STUDIES OF THE EFFECT OF MISMATCHES ON TRIPLEX STABILITY [J].

MERGNY, JL ;

SUN, JS ;

ROUGEE, M ;

MONTENAYGARESTIER, T ;

BARCELO, F ;

CHOMILIER, J ;

HELENE, C .

BIOCHEMISTRY, 1991, 30 (40) :9791-9798

[9] SELECTIVE MODIFICATION OF CYTOSINES IN OLIGODEOXYRIBONUCLEOTIDES [J].

MILLER, PS ;

CUSHMAN, CD .

BIOCONJUGATE CHEMISTRY, 1992, 3 (01) :74-79

[10] TRIPLEX FORMATION BY OLIGODEOXYRIBONUCLEOTIDES INVOLVING THE FORMATION OF X.U.A TRIADS [J].

MILLER, PS ;

CUSHMAN, CD .

BIOCHEMISTRY, 1993, 32 (12) :2999-3004

← 1 2 →