ANTIARTHRITIC EFFECTS DEMONSTRATED BY AN INTERLEUKIN-2 RECEPTOR-TARGETED CYTOTOXIN (DAB486IL-2) IN RAT ADJUVANT ARTHRITIS

被引：26

作者：

BACHA, P ^{[1
]}

FORTE, SE ^{[1
]}

PERPER, SJ ^{[1
]}

TRENTHAM, DE ^{[1
]}

NICHOLS, JC ^{[1
]}

机构：

[1] BETH ISRAEL HOSP,DIV RHEUMATOL,BOSTON,MA 02215

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 07期

关键词：

D O I：

10.1002/eji.1830220702

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

DAB486IL-2 is an interleukin-2 receptor-specific cytotoxin which selectively targets and kills cells which bear the high-affinity form of the IL-2 receptor. Since elimination of activated T lymphocytes may be useful in the treatment of rheumatoid arthritis, the effect of DAB486IL-2 treatment in an animal model of arthritis was investigated. We demonstrated that rats treated with DAB486IL-2 during the induction phase of disease have delayed onset of symptoms and significantly reduced severity of inflammation as well as a depressed proliferative response to mycobacterial stimulation in vitro. In addition, the presence of preexisting antibodies to the molecule had no impact on the anti-arthritic effects observed in this model.These data suggest that DAB486IL-2 may have therapeutic potential in the treatment of rheumatoid arthritis.

引用

页码：1673 / 1679

页数：7

共 24 条

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