CLASS-I AND CLASS-II MAJOR HISTOCOMPATIBILITY MOLECULES PLAY A ROLE IN BONE-MARROW-DERIVED MACROPHAGE DEVELOPMENT

被引：7

作者：

ARMSTRONG, JW

SIMSKE, SJ

BEHARKA, AA

BALCH, S

LUTTGES, MW

CHAPES, SK

机构：

[1] KANSAS STATE UNIV AGR & APPL SCI, DIV BIOL, MANHATTAN, KS 66506 USA

[2] UNIV COLORADO, DEPT AEROSP ENGN SCI, BOULDER, CO 80309 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 1994年 / 55卷 / 05期

关键词：

MHC; MACROPHAGES; COLONY-STIMULATING FACTOR 1; HEMATOPOIESIS;

D O I：

10.1002/jlb.55.5.658

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Class I and class II major histocompatibility complex (MHC) molecules play significant roles in T cell development and immune function. We show that MHCI- and MHCII-deficient mice have low numbers of macrophage precursors and circulating monocytes, as well as abnormal bone marrow cell colony-stimulating factor type 1 secretion and bone composition. We suggest that MHCI and MHCII molecules play a significant role in macrophage development.

引用

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页码：658 / 661

页数：4

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