SERUM CYTOKINES IN PATIENTS WITH RHEUMATOID-ARTHRITIS - CORRELATION OF INTERFERON-GAMMA AND TUMOR-NECROSIS-FACTOR-ALPHA WITH THE CHARACTERISTICS OF PERIPHERAL-BLOOD MONONUCLEAR-CELLS

被引:20
作者
SAKITO, S
UEKI, Y
EGUCHI, K
KAWABE, Y
NAGATAKI, S
机构
[1] NAGASAKI UNIV,SCH MED,DEPT INTERNAL MED 1,NAGASAKI 852,JAPAN
[2] SASEBO CENT HOSP,NAGASAKI 857,JAPAN
关键词
RHEUMATOID ARTHRITIS; IL-1-BETA; TNF-ALPHA; IFN-GAMMA; ACTIVITY INDEX;
D O I
10.1007/BF00286766
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Serum cytokines such as interleukin 1 beta (IL-1 beta), interferon gamma (IFN-gamma), and tumor necrosis factor alpha (TNF alpha) were measured in 40 patients with rheumatoid arthritis (RA). In the 40 patients studied, serum IL-1 beta was detected in 5 patients, IFN-gamma in 10 patients, and TNF alpha in 20 patients. The IL-1 beta-positive group showed increased values of activity indices compared to the IL-1 beta-negative group. Values of serum IFN-gamma correlated well with the number of peripheral blood lymphocytes and CD3(+) cells and with the percentage of CD3(+) CD26(+) cells. Values of serum TNF alpha correlated positively with the number of peripheral blood monocytes and the percentage of CD3(+)HLA-DR(+) and CD3(+)CD25(+) cells. These results indicated that serum IL-1 beta in RA patients reflects the activity of RA, while the serum IFN-gamma and TNF alpha in RA patients may be related to circulating activated lymphocytes and monocytes, respectively,
引用
收藏
页码:31 / 37
页数:7
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