EFFECTS OF HEAVY-ATOM SALTS ON THE LUMINESCENCE PROPERTIES OF TETROL I-1 ON ALPHA-CYCLODEXTRIN SALT MATRICES

被引：11

作者：

CORLEY, J ^{[1
]}

HURTUBISE, RJ ^{[1
]}

机构：

[1] UNIV WYOMING,DEPT CHEM,LARAMIE,WY 82071

来源：

APPLIED SPECTROSCOPY | 1994年 / 48卷 / 06期

关键词：

BENZO(A)PYRENE-DNA ADDUCT; TETROLS; HEAVY-ATOM EFFECT; SOLID-MATRIX LUMINESCENCE;

D O I：

10.1366/000370294774368884

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Benzo(a)pyrene [B(a)P] is one of the most widely studied polyaromatic hydrocarbons. In the human body and in lower animals, B(a)P can become chemically bonded to DNA. Tetrols are the products obtained from the hydrolysis of B(a)P-DNA adducts. It has been proposed that the amount of tetrols detected in human body fluids can be used as a measure of the amount of B(a)P-DNA adducts present in the body. The effects of several heavy-atom salts on the solid-matrix fluorescence and phosphorescence properties of the tetrols were investigated. TlNO3 and TlF were very useful in enhancing the room-temperature phosphorescence (RTP) of the tetrols. For tetrol I-1 on 1:1:8 alpha-cyclodextrin:TlNO3: NaNO3, the limit of detection was 0.38 femtomole/mg. The RTP approach with the 1:1:8 alpha-cyclodextrin:TINO3:NaNO3 matrix would be useful for detecting subfemtomole quantities of the tetrols of B(a)P-DNA adducts from biological samples.

引用

页码：747 / 754

页数：8

共 40 条

[1] ROOM-TEMPERATURE LUMINESCENCE OF SEVERAL COMPOUNDS ON AN ALPHA-CYCLODEXTRIN-NACL MIXTURE [J].