CYTOKINES INVOLVED IN INTRATHYMIC T-CELL DEVELOPMENT

被引：9

作者：

HE, W

KABELITZ, D

机构：

[1] PAUL EHRLICH INST, DEPT IMMUNOL, D-63225 LANGEN, GERMANY

[2] UNIV HEIDELBERG, INST IMMUNOL & SEROL, HEIDELBERG, GERMANY

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1994年 / 105卷 / 03期

关键词：

T CELL PRECURSOR; T CELL RECEPTOR; CYTOKINES; INTERLEUKINS; T CELL DEVELOPMENT; THYMOCYTES;

D O I：

10.1159/000236759

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cytokines play an important role in intrathymic T cell development. Over the past several years, genes of newly discovered cytokines have been cloned, and the respective recombinant proteins have become available for functional studies of T cell development. In this paper we have attempted to review the respective roles of interleukins 1, 2, 4, 6, and 7. Special emphasis was given to interleukin 7 which has been shown to play a key role in early T cell differentiation.

引用

页码：203 / 210

页数：8

共 68 条

[1]

APPASAMY PM, 1992, J IMMUNOL, V149, P1649

[2]

ARMITAGE RJ, 1990, J IMMUNOL, V144, P938

[3] A ROLE FOR INTERLEUKIN-4 IN THE DIFFERENTIATION OF MATURE T-CELL RECEPTOR-GAMMA-DELTA+ CELLS FROM HUMAN INTRATHYMIC T-CELL PRECURSORS [J].