PROLONGED INCREASE IN BLOOD-PRESSURE BY A SINGLE ORAL DOSE OF CAFFEINE IN MILDLY HYPERTENSIVE MEN

被引：33

作者：

SUNG, BH

WHITSETT, TL

LOVALLO, WR

ALABSI, M

PINCOMB, GA

WILSON, MF

机构：

[1] Department of Medicine, State University of New York (BHS, MFW), Millard Fillmore Hospitals (BHS, MFW), Buffalo, NY

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1994年 / 7卷 / 08期

关键词：

CAFFEINE; HYPERTENSION; HEMODYNAMICS;

D O I：

10.1093/ajh/7.8.755

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Caffeine is known to raise blood pressure (BP). We examined a single oral dose of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee) on BP in 18 hypertensive (HTN) and 12 age-matched, normotensive (NT) men for 3 h. Systolic BPs were significantly higher after caffeine for -both groups (P < .001) for the entire 3 h. The HTN group showed persistent elevation in diastolic BP for 3 h, whereas the increment of diastolic BP became smaller in the NT group 90 min after caffeine ingestion. Our results suggest that caffeine consumption may affect both diagnosis and treatment of hypertension and abstinence from caffeine may be beneficial, especially for hypertensive individuals.

引用

页码：755 / 758

页数：4

共 15 条

[1]

Robertson D., Frolich J.C., Carr K., Et al., Effects of caffeine on plasma renin activity, catecholamines, and blood pressure, N Engl J Med, 298, pp. 181-186, (1978)

[2]

Whitsett T.L., Manion C.V., Christensen H.D., Cardiovascular effects of coffee and caffeine, Am J Cardiol, 53, pp. 918-922, (1984)

[3]

Smits P., Thien T., Van'Tlaar A., Circulatory effects of coffee in relation to the pharmacokinetics of caffeine, Am J Cardiol, 56, pp. 958-963, (1985)

[4]

Pincomb G.A., Lovallo W.R., Passey R.B., Et al., Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men, Am J Cardiol, 56, pp. 119-122, (1985)

[5]

Sung B.H., Lovallo W.R., Pincomb G.A., Wilson M.F., Effects of caffeine on blood pressure response during exercise in normotensive young men, Am J Cardiol, 65, pp. 909-913, (1990)

[6]

Lane J.D., Williams R.B., Cardiovascular effects of caffeine and stress in regular coffee drinkers, Psychophysiol, 24, pp. 157-164, (1987)

[7]

Lang T., Degoulet P., Aime F., Et al., Relation between coffee drinking and blood pressure: Analysis of 6, 321 subjects in the Paris region, Am J Cardiol, 52, pp. 1238-1242, (1983)

[8]

Shirlow M.J., Berry G., Stokes G., Caffeine consumption and blood pressure: An epidemiological study, Int J Epidemiol, 17, pp. 90-97, (1988)

[9]

Wilson M.F., Sung B.H., Pincomb G.A., Lovallo W.R., Simultaneous stroke volume measurement by impedance and nuclear ventriculography: Comparison at rest and during exercise interventions, Ann Biomed Engineer, 17, pp. 475-482, (1989)

[10]

Everson S.A., Lovallo W.R., Pincomb G.A., Et al., Validation of an ensemble-averaged impedance cardiogram for estimation of stroke volume, 13, pp. 801-802, (1991)

← 1 2 →