PATTERNS OF COAGULOPATHY DURING LIVER-TRANSPLANTATION - EXPERIENCE WITH THE FIRST 75 CASES USING THROMBELASTOGRAPHY

被引：50

作者：

MCNICOL, PL ^{[1
]}

LIU, G ^{[1
]}

HARLEY, ID ^{[1
]}

MCCALL, PR ^{[1
]}

PRZYBYLOWSKI, GM ^{[1
]}

BOWKETT, J ^{[1
]}

ANGUS, PW ^{[1
]}

HARDY, KJ ^{[1
]}

JONES, RM ^{[1
]}

机构：

[1] AUSTIN HOSP,LIVER TRANSPLANT UNIT,HEIDELBERG,VIC 3084,AUSTRALIA

来源：

ANAESTHESIA AND INTENSIVE CARE | 1994年 / 22卷 / 06期

关键词：

SURGERY; LIVER TRANSPLANTATION; COAGULOPATHY; MEASUREMENT TECHNIQUES; THROMBELASTOGRAPHY;

D O I：

10.1177/0310057X9402200603

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Using both conventional laboratory clotting profile and thrombelastography, coagulation status was monitored intraoperatively during liver transplantation in the first 75 cases performed at the Austin Hospital between June 1988 and October 1992. Superimposed on a baseline coagulopathy due to liver disease is a specific pattern of coagulation disturbance which occurs during a liver transplant. Fibrinolysis occurs in the anhepatic stage, worsens with early reperfusion and then spontaneously resolves. In addition reperfusion is associated with a transient clotting defect. If blood loss is excessive, coagulopathy due to massive transfusion may compound the situation. Thrombelastography is a measurement technique allowing rapid on-site assessment of functional clotting status'. It is particularly useful in liver transplant surgery, In combination with clinical bleeding assessment it facilitates selective use of component therapy (fresh frozen plasma, platelets and cryoprecipitate) and specific drug treatment only when it is appropriate. It also acts as a liver function test, being especially useful in assessing the graft after reperfusion.

引用

页码：659 / 665

页数：7

共 35 条

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