IRREVERSIBLE ENZYME INHIBITORS .105. DIFFERENTIAL IRREVERSIBLE INHIBITION OF VERTEBRATE DIHYDROFOLIC REDUCTASES BY DERIVATIVES OF 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINES SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE

被引：77

作者：

BAKER, BR

LOURENS, GJ

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1967年 / 10卷 / 06期

关键词：

D O I：

10.1021/jm00318a029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1113 / +

页数：1

共 59 条

[1]

BAKER BH, TO BE PUBLISHED

[2]

BAKER BL, IN PRESS

[3] NON-CLASSICAL ANTIMETABOLITES .6. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR [J].

BAKER, BR ;

LEE, WW ;

TONG, E .

JOURNAL OF THEORETICAL BIOLOGY, 1962, 3 (03) :459-&

[4] ANALOGS OF TETRAHYDROFOLIC ACID .7. SYNTHESIS OF N-[1-(2-AMINO-4-HYDROXY-6-METHYL-5-PYRIMIDYL)-3-PROPYL]-P-AMINOBENZOYL-L-GLUTAMIC ACID, AN INHIBITOR OF FOLIC REDUCTASE [J].

BAKER, BR ;

MORREAL, CE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (09) :840-&

[5] ANALOGS OF TETRAHYDROFOLIC ACID .10. SYNTHETIC + ENZYMIC STUDIES ON CONTRIBUTION OF P-AMINOBENZOYL-L-GLUTAMATE MOIETY OF PYRIMIDYL ANALOGS TO BINDING TO SOME FOLIC COFACTOR AREA ENZYMES [J].

BAKER, BR ;

SANTI, DV ;

ALMAULA, PI ;

WERKHEISER, WC .

JOURNAL OF MEDICINAL CHEMISTRY, 1964, 7 (01) :24-&

[6] POTENTIAL ANTICANCER AGENTS .66. NON-CLASSICAL ANTIMETABOLITES .3. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR OF GLUTAMIC DEHYDROGENASE [J].

BAKER, BR ;

LEE, WW ;

ROSS, LO ;

TONG, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1961, 83 (17) :3713-&

[7] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[8] IRREVERSIBLE ENZYME INHIBITORS .104. INHIBITORS OF THYMIDINE PHOSPHORYLASE .8. FURTHER STUDIES ON HYDROPHOBIC BONDING WITH 6-SUBSTITUTED URACILS [J].

BAKER, BR ;

RZESZOTARSKI, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1109-+

[9] IRREVERSIBLE ENZYME INHIBITORS .83. CANDIDATE ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE .8. DERIVATIVES 2.4-DIAMINOPYRIMIDINE .2. [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1967, 4 (01) :31-&

[10] ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES [J].

BAKER, BR ;

HO, BT ;

SANTI, DV .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (10) :1415-&

← 1 2 3 4 5 6 →