SPONTANEOUS PRODUCTION OF INTERLEUKIN-1-LIKE FACTORS FROM PREGNANT RABBIT UTERINE CERVIX

被引：42

作者：

ITO, A ^{[1
]}

HIRO, D ^{[1
]}

OJIMA, Y ^{[1
]}

MORI, Y ^{[1
]}

机构：

[1] TOKYO COLL PHARM, DEPT BIOCHEM, 1432 HORINOUCHI, HACHIOJI, TOKYO 19203, JAPAN

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1988年 / 159卷 / 01期

关键词：

D O I：

10.1016/0002-9378(88)90532-7

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Uterine cervical explants in culture from pregnant rabbits at term spontaneously synthesized and secreted three species of interleukin-1-like factors in culture medium. The addition of the exogenous mitogen lipopolysaccharide to the culture system induced further release of these factors. However, these phenomen were not observed with explants from nonpregnant cervices. The molecular weights of these factors estimated by gel filtration were approximately 49, 22, and 12 kDa, respectively. These results indicate that interleukin-1-like factors are involved in cervical ripening and dilatation, especially in the acceleration of collagenase production, at term.

引用

页码：261 / 265

页数：5

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