EFFECTS OF SOTALOL AND PROPRANOLOL ADMINISTERED ORALLY IN MAN

The potency and duration of the effects of a new adrenergic beta-receptor blocking agent, sotalol (DL-4-(2-isopropylamino-1-hydroxylethyl) methanesulphonanilide, MJ 1999) were compared to those of propranolol on 5 male subjects. Both compounds administered by mouth significantly reduced the circulatory and metabolic effects of intravenously infused L-isoproterenol. During the first four hours after administration 40 mg sotalol or 40 mg propranolol both reduced the effects of isoproterenol by about 70 per cent; 80 mg sotalol was more effective, reducting the effects by 80-90 percent. At 7 hours the effects of sotalol (40 and 80 mg) were significantly larger, at 24 hours half of the antagonism remained, while that of propranolol had completely disappeared. In man sotalol is more stable than propranolol. © 1969.