ALPHA-1-ACID GLYCOPROTEIN EXPRESSION IN HUMAN-LEUKOCYTES - POSSIBLE CORRELATION BETWEEN ALPHA-1-ACID GLYCOPROTEIN AND INFLAMMATORY CYTOKINES IN RHEUMATOID-ARTHRITIS

被引：37

作者：

NAKAMURA, T

BOARD, PG

MATSUSHITA, K

TANAKA, H

MATSUYAMA, T

MATSUDA, T

机构：

[1] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT INTERNAL MED 1,CANBERRA,ACT 2601,AUSTRALIA

[2] AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DIV CLIN SCI,MOLEC GENET GRP,CANBERRA,ACT 2601,AUSTRALIA

[3] KAGOSHIMA UNIV,FAC MED,DEPT IMMUNOL & MED ZOOL,KAGOSHIMA 890,JAPAN

[4] KAGOSHIMA RED CROSS HOSP,CTR RHEUMAT,KAGOSHIMA 89101,JAPAN

来源：

INFLAMMATION | 1993年 / 17卷 / 01期

关键词：

D O I：

10.1007/BF00916390

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Alpha1-Acid glycoprotein is an acute-phase reactant that becomes markedly elevated in serum during inflammation and has an immunosuppressive effect on lymphocyte functions. Patients with collagen diseases had significant increases of alpha1-acid glycoprotein in their serum and on the surface of peripheral leukocytes compared with controls. The levels from patients with rheumatoid arthritis were higher than those from patients with systemic lupus erythematosus, mixed connective tissue disease, and Behcet's disease. In patients with rheumatoid arthritis, the value of serum alpha1-acid glycoprotein correlated with disease activity. Among leukocyte subpopulations, monocytes showed more alpha1-acid glycoprotein on their surface than polymorphonuclear leukocytes and lymphocytes. The cell surface expression of alpha1-acid glycoprotein on cultured monocytes surface peaked after 48 h. Interleukin-1beta and tumor necrosis factor-alpha stimulated the production of alpha1-acid glycoprotein RNA message in peripheral blood mononuclear cells over 18-24 h during cell culture The results show that serum alpha1-acid glycoprotein reflects systemic disease activity in rheumatoid arthritis. Furthermore, monocytes may serve as a source of production of alpha1-acid glycoprotein.

引用

页码：33 / 45

页数：13

共 45 条

[1]

AOZASA K, 1987, CANCER, V60, P2424, DOI 10.1002/1097-0142(19871115)60:10<2424::AID-CNCR2820601012>3.0.CO

[2]

2-2

[3] THE AMERICAN-RHEUMATISM-ASSOCIATION 1987 REVISED CRITERIA FOR THE CLASSIFICATION OF RHEUMATOID-ARTHRITIS [J].

ARNETT, FC ;

EDWORTHY, SM ;

BLOCH, DA ;

MCSHANE, DJ ;

FRIES, JF ;

COOPER, NS ;

HEALEY, LA ;

KAPLAN, SR ;

LIANG, MH ;

LUTHRA, HS ;

MEDSGER, TA ;

MITCHELL, DM ;

NEUSTADT, DH ;

PINALS, RS ;

SCHALLER, JG ;

SHARP, JT ;

WILDER, RL ;

HUNDER, GG .

ARTHRITIS AND RHEUMATISM, 1988, 31 (03) :315-324

[4]

BAUMAN H, 1987, J BIOL CHEM, V272, P9756

[5] MOLECULAR-CLONING AND NUCLEOTIDE-SEQUENCE OF HUMAN ALPHA-1 ACID GLYCOPROTEIN CDNA [J].

BOARD, PG ;

JONES, IM ;

BENTLEY, AK .

GENE, 1986, 44 (01) :127-131

[6]

BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77

[7] RECOMBINANT HUMAN INTERLEUKIN-6 (IL-6/BSF-2/HSF) REGULATES THE SYNTHESIS OF ACUTE PHASE PROTEINS IN HUMAN HEPATOCYTES [J].

CASTELL, JV ;

GOMEZLECHON, MJ ;

DAVID, M ;

HIRANO, T ;

KISHIMOTO, T ;

HEINRICH, PC .

FEBS LETTERS, 1988, 232 (02) :347-350

[8]

CASTELLO M, 1979, NATURE, V281, P677

[9]

CHIU KM, 1977, IMMUNOLOGY, V32, P997

[10]

CHOMCZYNSKI P, 1987, ANAL BIOCHEM, V162, P156, DOI 10.1016/0003-2697(87)90021-2

← 1 2 3 4 5 →