HUMORAL AND CELLULAR ACTIVATION IN A SIMULATED EXTRACORPOREAL CIRCUIT

被引：50

作者：

MOAT, NE ^{[1
]}

REBUCK, N ^{[1
]}

SHORE, DF ^{[1
]}

EVANS, TW ^{[1
]}

FINN, AHR ^{[1
]}

机构：

[1] SHEFFIELD CHILDRENS HOSP,SHEFFIELD S10 2TH,S YORKSHIRE,ENGLAND

来源：

ANNALS OF THORACIC SURGERY | 1993年 / 56卷 / 06期

关键词：

D O I：

10.1016/0003-4975(93)90742-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Endothelial injury consequent upon widespread humoral and cellular activation is probably a major contributor to the phenomenon of cardiopulmonary bypass-induced organ dysfunction. This article reviews some of the mechanisms by which complement and neutrophil activation and interleukin-8 may be involved in this inflammatory response. In a model consisting of a simulated extracorporeal circulation we were able to demonstrate complement activation, profound and specific changes in neutrophil adhesion molecule expression, and interleukin-8 generation. The importance of these changes and their potential interactions are discussed.

引用

页码：1509 / 1514

页数：6

共 44 条

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