SYNTHESIS OF CHIRAL BUILDING-BLOCKS USING PSEUDOMONAS-FLUORESCENS LIPASE-CATALYZED ASYMMETRIC HYDROLYSIS OF MESO-DIACETATES

被引：37

作者：

XIE, ZF ^{[1
]}

SUEMUNE, H ^{[1
]}

SAKAI, K ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

来源：

TETRAHEDRON-ASYMMETRY | 1993年 / 4卷 / 05期

关键词：

ASYMMETRIC HYDROLYSIS; PSEUDOMONAS-FLUORESCENS LIPASE; MESO-DIACETATE; CHIRAL BUILDING BLOCK; (-)-MUSCONE;

D O I：

10.1016/S0957-4166(00)80142-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two chiral building blocks were prepared using a lipase-catalyzed asymmetric hydrolysis of the corresponding meso-diacetates. The chirality in the hydrolyzed products was conveniently incorporated into that of (R)-muscone and hunger modulator.

引用

页码：973 / 980

页数：8

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