AUTORADIOGRAPHIC ANALYSIS OF SEROTONIN RECEPTORS AND TRANSPORTER IN KINDLED RAT-BRAIN

被引：21

作者：

CLARK, M

WEISS, SRB

POST, RM

机构：

[1] Biological Psychiatry Branch, National Institute of Mental Health, Bethesda

来源：

NEUROSCIENCE LETTERS | 1993年 / 161卷 / 01期

关键词：

HIPPOCAMPUS; SEROTONIN RECEPTOR; SEROTONIN TRANSPORTER; ADENOSINE A1 RECEPTOR; AUTORADIOGRAPHY; KINDLING; RAT BRAIN;

D O I：

10.1016/0304-3940(93)90130-D

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While serotonin (5-HT) has been shown to be anticonvulsant in several types of experimentally induced seizures, 5-HT receptor binding has not been investigated in the kindling model of epilepsy. The present study examined the effects of amygdala kindling on two 5-HT receptor subtypes and on the 5-HT transporter in rat brain. Kindling induced a persistent bilateral increase in 5-HT1A binding in the dentate gyrus, while 5-HT1B receptors increased only in a delayed fashion. Binding to the 5-HT transporter was transiently decreased in dentate gyrus. In cerebral cortex, binding of the three ligands was unchanged. Alterations in 5-HT receptors and the 5-HT transporter may endogenously modulate kindled seizures. Additionally, autoradiography of adenosine A1 receptors revealed no change for these receptors in any brain region.

引用

页码：21 / 26

页数：6

共 25 条

[1] THE GABA HYPOTHESIS OF KINDLING - RECENT ASSAY STUDIES [J].