ORAL BIOAVAILABILITY OF HEPARIN USING A NOVEL DELIVERY SYSTEM

被引:11
作者
DUNN, JM [1 ]
HOLLISTER, AS [1 ]
机构
[1] UNIV COLORADO, SCH MED, DIV CLIN PHARMACOL & TOXICOL, DENVER, CO USA
来源
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1995年 / 56卷 / 08期
关键词
D O I
10.1016/0011-393X(95)85057-0
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Heparin, a large molecule of approximately 20,000 d, was successfully entrapped into biodegradable nanospheres. The final product, at a dose of 2400 U/kg, was given orally with a hydrogel adjuvant to 12 rabbits. Plasma heparin was assayed by use of a validated standard anti-Xa chromogenic method. Elevated levels of plasma heparin were demonstrated for 144 hours after a single oral dose. Oral administration of heparin, heparin with adjuvant, or adjuvant alone (controls) did not result in measurable plasma heparin levels. The nanosphere entrapment of drugs with low bioavailability represents a novel oral delivery system for such agents and confers sustained-release characteristics.
引用
收藏
页码:738 / 745
页数:8
相关论文
共 10 条
[1]   The inhibition of blood clotting: An unidentified substance which acts in conjunction with heparin to prevent the conversion of prothrombin into thrombin [J].
Brinkhous, KM ;
Smith, HP ;
Warner, ED ;
Seegers, WH .
AMERICAN JOURNAL OF PHYSIOLOGY, 1939, 125 (04) :683-687
[2]   STRUCTURE-ACTIVITY RELATIONSHIP IN HEPARIN - A SYNTHETIC PENTASACCHARIDE WITH HIGH-AFFINITY FOR ANTI-THROMBIN-III AND ELICITING HIGH ANTI-FACTOR-XA ACTIVITY [J].
CHOAY, J ;
PETITOU, M ;
LORMEAU, JC ;
SINAY, P ;
CASU, B ;
GATTI, G .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 116 (02) :492-499
[3]   ANGIOGENESIS INHIBITION AND TUMOR-REGRESSION CAUSED BY HEPARIN OR A HEPARIN FRAGMENT IN THE PRESENCE OF CORTISONE [J].
FOLKMAN, J ;
LANGER, R ;
LINHARDT, RJ ;
HAUDENSCHILD, C ;
TAYLOR, S .
SCIENCE, 1983, 221 (4612) :719-725
[4]  
HIRSH J, 1991, NEW ENGL J MED, V324, P1565
[5]   HEPARIN - OLD DRUG WITH A NEW PARADIGM [J].
JAQUES, LB .
SCIENCE, 1979, 206 (4418) :528-533
[6]  
MAJERUS P W, 1990, P1311
[7]   THE THROMBOPLASTIC ACTION OF CEPHALIN [J].
McLean, Jay .
AMERICAN JOURNAL OF PHYSIOLOGY, 1916, 41 (02) :250-257
[8]  
OLIVECRONA T, 1977, FED PROC, V36, P60
[9]  
OLSSON P, 1963, ACTA MED SCAND, V173, P619
[10]  
ROSENBERG AD, 1987, HEMOSTASIS THROMBOSI, P1337