HLA ANTIGEN FREQUENCIES IN PATIENTS WITH PROGRESSIVE SYSTEMIC-SCLEROSIS AND MORPHEA

被引：21

作者：

FREUDENBERG, J ^{[1
]}

HOLZMANN, H ^{[1
]}

SCHNEIDER, S ^{[1
]}

KORTING, GW ^{[1
]}

机构：

[1] UNIV MAINZ,HAUT KLIN,D-6500 MAINZ,FED REP GER

来源：

ARCHIVES OF DERMATOLOGICAL RESEARCH | 1978年 / 263卷 / 02期

关键词：

HLA; Morphea; Progressive systemic sclerosis;

D O I：

10.1007/BF00446441

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Fortythree patients with progressive systemic sclerosis and 24 patients with morphea are typed for 30 antigens of the HLA-A and B series. There is an increase of the frequency of HLA-B8 in patients with progressive systemic sclerosis (37% vs. 20% in controls: P<0.001, Pcorr.=n.s.). The increase of the HLA-B8 frequency seems to be most pronounced in patients with a diffuse form of progressive systemic sclerosis. 4 out of 5 patients are HLA-B8 positive (P=0.00672). In patients with acrosclerosis is HLA-B8 only slightly increased (32%), but the increase is greater in male patients (44%) and in patients with an early onset of the disease (36%). With the exception of HLA-A1 there is no deviation of the frequencies of any other HLA antigen tested, especially not of HLA-Aw24. The number of patients with morphea is to small for statistical evaluation. © 1978 Springer-Verlag.

引用

页码：197 / 205

页数：9

共 17 条

[1] HLA ANTIGENS AND SUSCEPTIBILITY TO DISEASE [J].