EFFECT OF TRIMETHOPRIM-SULFONAMIDE, TRIMETHOPRIM AND SULFONAMIDE ON THE OCCURRENCE OF RESISTANT ENTEROBACTERIACEAE IN HUMAN INTESTINAL FLORA

After the administration of various antimicrobial agents for chemotherapeutic purposes a general change in the intestinal flora of the patient is often observed. In contrast, the combination trimethoprim-sulphonamide causes in most cases a strong selective decrease in the number of Enterobacteriaceae organisms for treatment periods as long as four to 12 weeks. The results correspond to clinical experience with trimethoprim-sulphonamide therapy in urinary tract infection where reinfections with resistant organisms are the exception. © 1979 Verlagsgesellschaft Otto Spatz.