IDENTIFICATION OF ALPHA-ADRENERGIC RECEPTORS IN ADIPOSE-TISSUE BY [H-3]DIHYDROERGOCRYPTINE BINDING

被引：7

作者：

BEGINHEICK, N

HOULIHAN, PA

SIGOUIN, J

机构：

来源：

CANADIAN JOURNAL OF BIOCHEMISTRY | 1979年 / 57卷 / 07期

关键词：

D O I：

10.1139/o79-132

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 3H-labelled alpha-adrenergic antagonist dihydroergocryptine has been found to bind specifically to hamster white adipocyte membranes. Binding is rapid and is inhibited by alpha but not beta antagonists. In addition, adrenergic agonists compete for this binding site in order of affinities equal to their activity as alpha-adrenergic agonists. The (-) stereoisomer of adrenaline is 10 times more potent than the (+) stereoisomer in inhibiting binding.

引用

页码：1047 / 1049

页数：3

共 12 条

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