MONOCLONAL GAMMOPATHIES IN HUMAN AGING - INCREASED OCCURRENCE WITH AGE AND CORRELATION WITH HEALTH-STATUS

被引:44
作者
LIGTHART, GJ
RADL, J
CORBERAND, JX
VANNIEUWKOOP, JA
VANSTAALDUINEN, GJ
VANHELMOND, DJW
HIJMANS, W
机构
[1] UNIV TOULOUSE RANGUEIL,DEPT HAEMATOL,TOULOUSE,FRANCE
[2] LEIDEN UNIV,CTR MED,DEPT PATHOL,GERONTOL SECT,2300 RC LEIDEN,NETHERLANDS
[3] LEIDEN UNIV,CTR MED,DEPT IMMUNOHAEMATOL & BLOODBANK,2300 RC LEIDEN,NETHERLANDS
[4] TNO,INST EXPTL GERONTOL,RIJSWIJK,NETHERLANDS
关键词
Aging; Immunosenescence; Monoclonal gammopathies; Paraproteinemias;
D O I
10.1016/0047-6374(90)90127-2
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
To determine the incidence of monoclonal gammopathies (MG) in relation to the aging process as such, and to evaluate the influence of disease on the occurrence of MG, we studied 439 elderly subjects aged 75-84 years. These individuals were categorized into 4 groups on the basis of their health status. There was a group of "optimally healthy" elderly, a group of "apparently healthy" residents of homes for the aged, a group of geriatric outpatients and a group of randomly chosen inpatients from a general hospital. Whereas no MG were detected in a control group of healthy young subjects aged 25-34 years, the frequency of MG in the aged groups ranged from 11% in the "optimally healthy" aged group to 38% in the inpatients group. In a tentative classification according to possible cause, most of the MG belonged to the pathogenetic category of immunodeficiency. There was a clear association of the occurrence of monoclonal gammopathies of this category with the health status. © 1990.
引用
收藏
页码:235 / 243
页数:9
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