PRIMARY STRUCTURE OF THE HUMAN ELAFIN PRECURSOR PREPROELAFIN DEDUCED FROM THE NUCLEOTIDE-SEQUENCE OF ITS GENE AND THE PRESENCE OF UNIQUE REPETITIVE SEQUENCES IN THE PROSEGMENT

被引：71

作者：

SAHEKI, T ^{[1
]}

ITO, F ^{[1
]}

HAGIWARA, H ^{[1
]}

SAITO, Y ^{[1
]}

KUROKI, J ^{[1
]}

TACHIBANA, S ^{[1
]}

HIROSE, S ^{[1
]}

机构：

[1] EISAI & CO LTD,TSUKUBA RES LABS,TSUKUBA 30026,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(05)80981-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human elafin gene was cloned and its entire nucleotide sequence was determined to deduce the amino acid sequence for the precursor of elafin, an elastase-specific inhibitor. The gene spans approximately 1.7 kb and is divided into 3 exons. The gene product preproelafin consists of 117 amino acids: the initiator Met, a putative 25-amino acid signal peptide, a pro-sequence of about 34 amino acids, and the C-terminal 57 amino acids for mature elafin. Possible covalent clotting of the prosegment and its physiological significance have been pointed out based on a remarkable sequence similarity between the pro-sequence and the guinea pig seminal clotting protein SVP-1. © 1992 Academic Press, Inc.

引用

页码：240 / 245

页数：6

共 19 条

[1] NOVEL PEPTIDE INHIBITOR (SPAI) OF NA+, K+-ATPASE FROM PORCINE INTESTINE [J].