CONTROLLING STEREOSELECTION IN INTRAMOLECULAR HECK REACTIONS BY TAILORING THE PALLADIUM CATALYST

被引:72
作者
MADIN, A [1 ]
OVERMAN, LE [1 ]
机构
[1] UNIV CALIF IRVINE,DEPT CHEM,IRVINE,CA 92717
关键词
D O I
10.1016/S0040-4039(00)61217-0
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Cyclization of the acryloyl 2'-bromoanilide 1a with a "ligandless" palladium(0) catalyst affords the pentacyclic oxindole 2a (ds = 9:1), while cyclization of 1a with a palladium(0) catalyst in the presence of a silver salt provides the stereoisomeric oxindole 3a (ds = 97:3).
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页码:4859 / 4862
页数:4
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