BRONCHIAL RESPONSIVENESS TO EXERCISE IN A RANDOM SAMPLE OF 494 CHILDREN AND ADOLESCENTS FROM COPENHAGEN

被引:53
作者
BACKER, V [1 ]
ULRIK, CS [1 ]
机构
[1] UNIV COPENHAGEN HOSP,RIGSHOSP,DEPT MED B,RESP PHYSIOL LAB,DK-2100 COPENHAGEN,DENMARK
关键词
D O I
10.1111/j.1365-2222.1992.tb02813.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
To investigate the bronchial response to exercise, we studied a random sample of 494 children and adolescents, aged 7-16 years, from Copenhagen. Exercise challenge consisted of steady running on a 10% sloping treadmill for 6 min in a climate chamber. Furthermore, in 464 subjects a histamine challenge test was also performed. Of the 494 subjects studied, 81 (16%) had at least 10% and 30 (6%) at least 15% reduction in FEV1 within 15 min after exercise. Twenty-nine (6%) subjects had bronchial hyperresponsiveness to both histamine and exercise, 48 (10%) subjects had bronchial hyperresponsiveness to exercise, but histamine responsiveness within the normal range, whereas 340 (73%) subjects had neither bronchial hyperresponsiveness to exercise nor inhaled histamine. With regard to the presence of asthma defined as substantial exercise induced bronchoconstriction (DELTA-FEV1 greater-than-or-equal-to 10%), exercise testing may not be appropriate for identifying clinical asthma in a random sample, because the highest predictive value of a positive test was 25%. On the other hand, a history of clinical asthma was frequently associated with increased bronchial responsiveness to exercise (77%). In conclusion, 16% of a random sample of children and adolescents had abnormal bronchial responsiveness to exercise (DELTA-FEV1 greater-than-or-equal-to 10%), 6% of the subjects had a DELTA-FEV1 greater-than-or-equal-to 15%. Furthermore, because of a low predictive value of a positive test, the exercise challenge test has only a supplementary role in the detection of clinical asthma in population samples.
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收藏
页码:741 / 747
页数:7
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