MEASUREMENT OF HISTAMINE METABOLITES IN BRAIN AND CEREBROSPINAL-FLUID PROVIDES INSIGHTS INTO HISTAMINERGIC ACTIVITY

被引：22

作者：

PRELL, GD

GREEN, JP

机构：

[1] Department of Pharmacology, Mount Sinai School of Medicine of the City University of New York, New York, 10029, NY

来源：

AGENTS AND ACTIONS | 1994年 / 41卷

关键词：

D O I：

10.1007/BF02007743

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Measurements of the concentrations of histamine's metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), in brain have been used to evaluate histamine turnover in brains of animals, and the same measurements in CSF have been used to infer histaminergic activity in brains of man. In regions of rat brain, half-lives of histamine are shorter than those of dopamine, 5-hydroxytryptamine and norepinephrine. Studies of human CSF suggest that brain histaminergic activity increases with age and is higher in females than in males.

引用

页码：C5 / C8

页数：4

共 32 条

[1] HIGHLY POTENT AND SELECTIVE LIGANDS FOR HISTAMINE RECEPTORS-H-3 [J].

ARRANG, JM ;

GARBARG, M ;

LANCELOT, JC ;

LECOMTE, JM ;

POLLARD, H ;

ROBBA, M ;

SCHUNACK, W ;

SCHWARTZ, JC .

NATURE, 1987, 327 (6118) :117-123

[2] DIFFERENT LOCALIZATION OF HISTIDINE DECARBOXYLASE AND HISTAMINE-N-METHYLTRANSFERASE IN RAT-BRAIN [J].

BISCHOFF, S ;

KORF, J .

BRAIN RESEARCH, 1978, 141 (02) :375-379

[3] EFFECTS OF AMINOGUANIDINE ON PREIRRADATION AND POSTIRRADIATION REGIONAL CEREBRAL BLOOD-FLOW, SYSTEMIC BLOOD-PRESSURE AND PLASMA HISTAMINE LEVELS IN THE PRIMATE [J].

COCKERHAM, LG ;

PRELL, GD ;

CERVENY, TJ ;

OBRIEN, M ;

HAMPTON, JD .

AGENTS AND ACTIONS, 1991, 32 (3-4) :237-244

[4] ASPECTS OF HISTAMINE-METABOLISM [J].

GREEN, JP ;

PRELL, GD ;

KHANDELWAL, JK ;

BLANDINA, P .

AGENTS AND ACTIONS, 1987, 22 (1-2) :1-15

[5]

GREEN JP, 1985, ADV BIOSCI, V51, P185

[6]

Hough L.B., 1984, HDB NEUROCHEMISTRY, V6, P145

[7] INHIBITION OF BRAIN HISTAMINE-METABOLISM BY METOPRINE [J].

HOUGH, LB ;

KHANDELWAL, JK ;

GREEN, JP .

BIOCHEMICAL PHARMACOLOGY, 1986, 35 (02) :307-310

[8] CELLULAR-LOCALIZATION AND POSSIBLE FUNCTIONS FOR BRAIN HISTAMINE - RECENT PROGRESS [J].

HOUGH, LB .

PROGRESS IN NEUROBIOLOGY, 1988, 30 (06) :469-505

[9] HISTAMINE TURNOVER IN REGIONS OF RAT-BRAIN [J].

HOUGH, LB ;

KHANDELWAL, JK ;

GREEN, JP .

BRAIN RESEARCH, 1984, 291 (01) :103-109

[10] CHARACTERIZATION OF HISTAMINE-RELEASE FROM THE RAT HYPOTHALAMUS AS MEASURED BY INVIVO MICRODIALYSIS [J].

ITOH, Y ;

OISHI, R ;

NISHIBORI, M ;

SAEKI, K .

JOURNAL OF NEUROCHEMISTRY, 1991, 56 (03) :769-774

← 1 2 3 4 →