KNOWLEDGE-BASED MODEL-BUILDING OF PROTEINS - CONCEPTS AND EXAMPLES

被引：89

作者：

BAJORATH, J ^{[1
]}

STENKAMP, R ^{[1
]}

ARUFFO, A ^{[1
]}

机构：

[1] UNIV WASHINGTON, DEPT BIOL STRUCT, SEATTLE, WA 98195 USA

来源：

PROTEIN SCIENCE | 1993年 / 2卷 / 11期

关键词：

PROTEIN MODELING; PROTEIN STRUCTURE; SEQUENCE SIMILARITY; SEQUENCE-STRUCTURE COMPATIBILITY; STRUCTURAL SIMILARITY;

D O I：

10.1002/pro.5560021103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe how to build protein models from structural templates. Methods to identify structural similarities between proteins in cases of significant, moderate to low, or virtually absent sequence similarity are discussed. The detection and evaluation of structural relationships is emphasized as a central aspect of protein modeling, distinct from the more technical aspects of model building. Computational techniques to generate and complement comparative protein models are also reviewed. Two examples, P-selectin and gp39, are presented to illustrate the derivation of protein model structures and their use in experimental studies.

引用

页码：1798 / 1810

页数：13

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