SIALYLTRANSFERASE - A NOVEL ACUTE-PHASE REACTANT

被引：48

作者：

JAMIESON, JC

MCCAFFREY, G

HARDER, PG

机构：

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1993年 / 105卷 / 01期

关键词：

D O I：

10.1016/0305-0491(93)90165-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. Proteins that are released into the circulation in elevated amounts in injured mammals are referred to as acute-phase reactants. Most are liver synthesized glycoproteins of the secretable type. However, Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase (EC 2.4.99.1) is a novel acute-phase reactant since it is a Golgi membrane-bound enzyme rather than a secretable glycoprotein. 2. The role of glucocorticoids and cytokines in the control of synthesis and expression of acute-phase glycoproteins, including sialyltransferase, is discussed. 3. The acute-phase behaviour of Gal-beta(1-->4)-GlcNAc-alpha(2-->6)-sialyltransferase is dependent on the release of the enzyme from the Golgi in the acute-phase state. The mechanism of release of a catalytically active form of the enzyme is described.

引用

页码：29 / 33

页数：5

共 40 条

[1]

BAUMANN H, 1991, J BIOL CHEM, V266, P20424

[2]

BAUMANN H, 1983, J BIOL CHEM, V258, P563

[3]

BAUMANN H, 1990, J BIOL CHEM, V265, P22275

[4]

BAUMANN H, 1984, J BIOL CHEM, V259, P7331

[5]

BAUMANN H, 1991, J BIOL CHEM, V266, P20390

[6] COMPARISON OF L-SELECTIN AND E-SELECTIN LIGAND SPECIFICITIES - THE L-SELECTIN CAN BIND THE E-SELECTIN LIGANDS SIALYL LEX AND SIALYL LEA [J].

BERG, EL ;

MAGNANI, J ;

WARNOCK, RA ;

ROBINSON, MK ;

BUTCHER, EC .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 184 (02) :1048-1055

[7]

COLLEY KJ, 1989, J BIOL CHEM, V264, P17619

[8]

COLLEY KJ, 1992, J BIOL CHEM, V267, P7784

[9] GENE-REGULATION BY INTERLEUKIN-6 [J].

FEY, GH ;

HATTORI, M ;

HOCKE, G ;

BRECHNER, T ;

BAFFET, G ;

BAUMANN, M ;

BAUMANN, H ;

NORTHEMANN, W .

BIOCHIMIE, 1991, 73 (01) :47-50

[10] THE 3 MEMBERS OF THE SELECTIN RECEPTOR FAMILY RECOGNIZE A COMMON CARBOHYDRATE EPITOPE, THE SIALYL LEWIS OLIGOSACCHARIDE [J].

FOXALL, C ;

WATSON, SR ;

DOWBENKO, D ;

FENNIE, C ;

LASKY, LA ;

KISO, M ;

HASEGAWA, A ;

ASA, D ;

BRANDLEY, BK .

JOURNAL OF CELL BIOLOGY, 1992, 117 (04) :895-902

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