SYNTHESIS OF TRIDEUTERIOMETHYL 5-DEUTERIUM-BETA-D-MANNOPYRANOSIDE

被引：2

作者：

GODDAT, J

DATTA, P

GREY, AA

CARVER, JP

SHAH, RN

机构：

[1] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO M5S 1A8,ONTARIO,CANADA

[2] UNIV TORONTO,CARBOHYDRATE RES CTR,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 1993年 / 12卷 / 06期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1080/07328309308019008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The title compound was prepared by first converting trideuteriomethyl 2,3,4-tri-O-benzyl-beta-D-mannopyranoside to a 6-bromo-6-deoxy derivative which on elimination by using DBU (1,8-diazabicyclo[5.4.0]undec-7-ene) or DBN (1,5-diazabicyclo[4.3.0]non-5-ene) gave a hex-5-enopyranoside derivative. The deuteroboration of the hex-5-enopyranoside followed by oxidation and subsequent deblocking produced trideuteriomethyl 5-deuterium-beta-D-mannopyranoside.

引用

页码：793 / 800

页数：8

共 9 条

[1] CARBOCYCLIC COMPOUNDS FROM MONOSACCHARIDES .2. TRANSFORMATIONS IN THE MANNOSE SERIES [J].