A STABILITY INDICATING HPLC ASSAY FOR PREDNISOLONE SODIUM-PHOSPHATE IN IMPLANTABLE INFUSION PUMPS

被引：5

作者：

BACHMAN, WJ

GAMBERTOGLIO, JG

机构：

[1] Division of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco

来源：

ANALYTICAL LETTERS | 1990年 / 23卷 / 05期

关键词：

High Performance Liquid Chromatography; Prednisolone Sodium Phosphate; Stability-Indicating;

D O I：

10.1080/00032719008052490

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A stability indicating assay for prednisolone sodium phosphate (PSP) in solutions for implantable infusion pumps was developed. PSP and its major breakdown product, prednisolone, were separated from formulation excipients by reverse phase chromatography on a phenyl-bonded phase column using an acetonitrile-phosphate buffer mobile phase. Detection was by ultraviolet absorbance at 243 nm. Recovery from a synthetic formulation was 101.0 ± 0.4% (n=6). The method was used to monitor the stability of PSP solutions in implantable infusion pumps maintained at 37 °C over a 21 day period. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：893 / 900

页数：8

共 4 条

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[3] ANALYSIS OF STEROID PHOSPHATES BY HIGH-PRESSURE LIQUID-CHROMATOGRAPHY - BETAMETHASONE SODIUM PHOSPHATE
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[4] 1989, US PHARMACOPEIA, P1133

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