FIMBRIA-FORNIX LESIONS IN AGED RATS CAUSE INCREASED CARBACHOL-STIMULATED PHOSPHOINOSITIDE HYDROLYSIS IN THE HIPPOCAMPUS, BUT NO CHANGE IN MUSCARINIC RECEPTOR-BINDING

被引：4

作者：

COURT, JA

KEITH, AB

KERWIN, JM

PERRY, EK

机构：

[1] MRC Neurochemical Pathology Unit, Newcastle General Hospital, Newcastle upon Tyne

来源：

BRAIN RESEARCH | 1990年 / 532卷 / 1-2期

关键词：

Aged; Fimbria/fornix lesion; Muscarinic receptor; Phosphoinositide hydrolysis; Rat;

D O I：

10.1016/0006-8993(90)91778-F

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Electrolytic lesions of the fimbria/fornix in 26-month-old rats led to an enhanced phosphionosite (PI) hydrolysis in response to carbachol in hippocampal slices, 11-15 days after surgery. The lesions caused a 78% reduction of choline acetyltransferase but no change in muscarinic binding. The PI response to carbachol and the enhancement of this after lesioning were not as great as that previously reported in young adult rats. © 1990.

引用

页码：333 / 335

页数：3

共 15 条

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