TAUTOMERISM AND ACIDITY IN 4-QUINOLONE-3-CARBOXYLIC ACID-DERIVATIVES

被引：48

作者：

DELACRUZ, A

ELGUERO, J

GOYA, P

MARTINEZ, A

PFLEIDERER, W

机构：

[1] CSIC,INST QUIM MED,JUAN CIERVA 3,E-28006 MADRID,SPAIN

[2] UNIV CONSTANCE,FAK MED,W-7750 CONSTANCE,GERMANY

来源：

TETRAHEDRON | 1992年 / 48卷 / 29期

关键词：

D O I：

10.1016/S0040-4020(01)89860-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Prototropic tautomerism in 4-quinolone-3-carboxylic acid derivatives has been studied with particular emphasis on the influence of the ring substituents on the equilibrium. The techniques used include UV, H-1-NMR, C-13-NMR (solution) and C-13-NMR CP/MAS (solid state) and semiempirical and ab initio calculations. The pK(a) values of some quinolone derivatives have been determined and correlated with data obtained from semiempirical methods.

引用

页码：6135 / 6150

页数：16

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