GASTRIC PRESSURE RESPONSE TO LOW-DOSE DOPAMINE INFUSION IN NORMAL MAN

被引：9

作者：

HARTLEY, MN ^{[1
]}

SARGINSON, RF ^{[1
]}

GREEN, CJ ^{[1
]}

PARR, NJ ^{[1
]}

DUCKWORTH, R ^{[1
]}

MAYCOCK, PF ^{[1
]}

FAIRHURST, JA ^{[1
]}

CAMPBELL, IT ^{[1
]}

机构：

[1] UNIV LIVERPOOL,ROYAL LIVERPOOL HOSP,DEPT ANAESTHESIA,LIVERPOOL L69 3BX,ENGLAND

来源：

CLINICAL NUTRITION | 1992年 / 11卷 / 01期

关键词：

D O I：

10.1016/0261-5614(92)90059-Y

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The gastric pressure response to distension was measured during intravenous infusion of dopamine at a rate of 2-mu-g min-1 kg-1 over 2 h 50 min in 5 normal volunteers to determine whether dopamine at this dose potentiated gastric adaptive relaxation, leading to a fall in gastric pressure and thus a potential delay in gastric emptying. This would be of obvious importance in patients being given dopamine at this dose to support renal function and at the same time being fed by nasogastric tube. The pressure response decreased during the first hour in all five subjects (p < 0.01). In 2 it recovered during the third hour to pre-infusion values, but in 2 it remained diminished; in 1 subject the results were equivocal. Circulating dopamine, noradrenaline and adrenaline concentrations all increased during dopamine (p < 0.05), but compared with control there was no difference in plasma free fatty acids, glycerol, cortisol or glucose concentrations. Dopamine at 2-mu-g min-1 kg-1 produced a transient fall in gastric pressure in all subjects, and a persistent fall in some. The changes in gastric pressures were seen at infusion rates that produced no metabolic or inotropic effects.

引用

页码：23 / 29

页数：7

共 12 条

[1]

Valenzeula, Dopamine as a possible neurotransmitter in gastric relaxation, Gastroenterology, 71, pp. 1019-1022, (1976)

[2]

Sinnett, Leathard, Domperidone: its effect on human gastric adaptive relaxation, Royal Society of Medicine. International Congress and Symposium Series: Hamburg. No. 36, pp. 43-48, (1980)

[3]

Kelly, Gastric emptying of liquids and solids: roles of proximal and distal stomach, American Journal of Physiology, 239, pp. G71-G76, (1980)

[4]

Association of British Pharmaceutical Industries, ABPI-data sheet compendium 1989–1990, pp. 443-444, (1990)

[5]

Valenzeula, Liu, The effect of variations in intragastric pressure and gastric emptying of a saline meal in humans, Scandinavian Journal of Gastroenterology, 17, pp. 293-296, (1982)

[6]

Muller-Lissner, Fraas, Hartl, Cisapride offsets dopamine-induced slowing of fasting gastric emptying, Digestive Diseases and Sciences, 31, pp. 807-810, (1986)

[7]

Bateman, Dopamine and the gastric emptying of a liquid, British Journal of Clinical Pharmacology, 15, (1983)

[8]

Hartley, Walker, Mackie, Abnormal gastric adaptive relaxation in patients with gastro-osophageal reflux, Gut, 31, pp. 500-503, (1990)

[9]

Abumrad, Rabin, Diamond, Lacy, Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man, Metabolism, 30, pp. 936-940, (1981)

[10]

Harrison, Hodson, Skillen, Stappenbeck, Agius, Alberti, Blood glucose, lactate, pyruvate, glycerol, 3-hydroxybutyrate and acetoacetata measurements in man using a centrifugal analyser with a fluorimetric attachment, Journal of Clinical Chemistry and Clinical Biochemistry, 26, pp. 141-146, (1988)

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