DISCREPANCY BETWEEN PNMT PRESENCE AND RELATIVE LACK OF ADRENALINE PRODUCTION IN EXTRAADRENAL PHEOCHROMOCYTOMA

被引：24

作者：

FUNAHASHI, H ^{[1
]}

IMAI, T ^{[1
]}

TANAKA, Y ^{[1
]}

TOBINAGA, JI ^{[1
]}

WADA, M ^{[1
]}

MATSUYAMA, T ^{[1
]}

TSUKAMURA, K ^{[1
]}

YAMADA, F ^{[1
]}

TAKAGI, H ^{[1
]}

NARITA, T ^{[1
]}

KOSHIKAWA, T ^{[1
]}

机构：

[1] AICHI CANC CTR,DEPT PATHOL,NAGOYA,AICHI 464,JAPAN

来源：

JOURNAL OF SURGICAL ONCOLOGY | 1994年 / 57卷 / 03期

关键词：

CATECHOLAMINE SYNTHESIZING ENZYMES; IMMUNOHISTOCHEMISTRY; URINARY CATECHOLAMINE LEVELS;

D O I：

10.1002/jso.2930570312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Among catecholamine synthesizing enzymes, phenylethanolamine-N-methyltransferase (PNMT) exists only in adrenal and extra-adrenal pheochromocytoma has been believed not to produce adrenaline. However, adrenaline production is clinically active in some extra-adrenal cases. To investigate this controversy, the localization of catecholamine synthesizing enzymes was studied by immunohistochemical staining in extra-adrenal and adrenal cases. The results showed that PNMT was expressed not only in many cases of-adrenal pheochromocytoma, but also in extra-adrenal pheochromocytoma. It is suspected that little adrenaline production in extra-adrenal cases is attributable to a lack of a good environment for the activation of PNMT by a high concentration of glucocorticoids. (C) 1994 Wiley-Liss, Inc.

引用

页码：196 / 200

页数：5

共 8 条

[1]

ENGELMAN K, 1968, LANCET, V23, P609

[2] GLUCOCORTICOIDS STIMULATE TRANSCRIPTION OF THE RAT PHENYLETHANOLAMINE N-METHYLTRANSFERASE (PNMT) GENE INVIVO AND INVITRO [J].