EXTENDED HLA PROFILE OF AN INBRED ISOLATE - THE SCHMIEDELEUT-HUTTERITES OF SOUTH-DAKOTA

被引:9
作者
DAWSON, DV
OBER, C
KOSTYU, DD
机构
[1] DUKE UNIV,MED CTR,DEPT IMMUNOL,DURHAM,NC
[2] UNIV CHICAGO,DEPT OBSTET & GYNECOL,CHICAGO,IL 60637
关键词
HLA; HAPLOTYPE ANALYSIS; LINKAGE DISEQUILIBRIUM; HUTTERITES; INBRED ISOLATE;
D O I
10.1002/gepi.1370120106
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
HLA-A, -B, -C, -DR, and -DQ typings of the Schmiedeleut Hutterites of South Dakota were collected as part of an ongoing genetic-epidemiologic study of HLA and fertility. A total of 1,082 individuals, including 852 married adults representative of the reproductive population of this isolate, were characterized for five-locus HLA haplotypes. HLA-A1, A2, A3, and A24 accounted for 75% of observed HLA-A alleles and HLA-B27, B35, B51, and B62 accounted for 55% of observed HLA-B alleles. S-leut Hutterites are derived from 68 or fewer ancestors. However, only 48 ancestral HLA haplotypes were observed and nine of these accounted for over 52% of the observed haplotypes. Measures of two-locus linkage disequilibrium derived from these haplotypes indicated that one-third to half of the observed HLA-A/B, B/DR, and A/DR allele combinations exhibited highly statistically significant linkage disequilibrium. Allele and haplotype frequencies did not differ between males and females. Recombination rates of 0.004% and 0.005% between HLA-A and -C and between HLA-B and -DR, respectively, were observed. This HLA profile points out a paucity of HLA alleles and haplotypes in this population and marked linkage disequilibrium among the HLA alleles that are present. (C) 1995 Wiley-Liss, Inc.
引用
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页码:47 / 62
页数:16
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