ORAL DELAYED-RELEASE SYSTEM FOR COLONIC SPECIFIC DELIVERY

被引：139

作者：

GAZZANIGA, A

IAMARTINO, P

MAFFIONE, G

SANGALLI, ME

机构：

[1] BOEHRINGER INGELHEIM ITALIA,I-20139 MILAN,ITALY

[2] UNIV PAVIA,DIPARTIMENTO CHIM FARMACEUT,PAVIA,ITALY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 108卷 / 01期

关键词：

COLONIC SPECIFIC DELIVERY; ORAL TIME-BASED SYSTEM; DELAYED RELEASE; FILM COATING; HIGH-VISCOSITY HPMC; SMALL INTESTINE TRANSIT TIME;

D O I：

10.1016/0378-5173(94)90418-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The paper describes a novel oral time-based drug release system for colonic specific delivery. The system, designed to exploit the relatively constant small intestine transit time of dosage forms, consists of drug-containing cores coated with three polymeric layers. The outer layer dissolves at pH > 5, then the intermediate swellable layer, made of high-viscosity HPMC, interacts slowly with aqueous fluids, thus providing the delay phase. The inner film is made of an enteric material. The system provides the expected delayed release pattern, as also indicated by the preliminary in vivo experiments on rats.

引用

收藏

页码：77 / 83

页数：7

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