HYDROXYLASE COFACTOR ACTIVITY IN CEREBROSPINAL-FLUID OF NORMAL SUBJECTS AND PATIENTS WITH PARKINSONS-DISEASE

被引：129

作者：

LOVENBERG, W

LEVINE, RA

ROBINSON, DS

EBERT, M

WILLIAMS, AC

CALNE, DB

机构：

[1] NIMH,CLIN SCI LAB,BETHESDA,MD 20014

[2] NINCDS,EXPTL THERAPEUT BRANCH,IRP,BETHESDA,MD 20014

来源：

SCIENCE | 1979年 / 204卷 / 4393期

关键词：

D O I：

10.1126/science.432666

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A method for measuring hydroxylase cofactor activity in human cerebrospinal fluid is described. The hydroxylase cofactor content of cerebrospinal fluid from Parkinsonian patients is approximately 50 percent that of normal subjects. A significant correlation between hydroxylase cofactor and the concentration of homovanillic acid in the cerebrospinal fluid was observed. Copyright © 1979 AAAS.

引用

页码：624 / 626

页数：3

共 8 条

[1] SIMULTANEOUS ASSAY BY MASS FRAGMENTOGRAPHY OF VANILLYL MANDELIC ACID, HOMOVANILLIC-ACID, AND 3-METHOXY-4-HYDROXY-PHENETHYLENE GLYCOL IN CEREBROSPINAL-FLUID AND URINE
GORDON, EK
OLIVER, J
BLACK, K
KOPIN, IJ
[J]. BIOCHEMICAL MEDICINE, 1974, 11 (01): : 32 - 40
[2] A SIMPLE RADIOISOTOPE ASSAY FOR PHENYLALANINE HYDROXYLASE COFACTOR
GUROFF, G
RHOADS, CA
ABRAMOWITZ, A
[J]. ANALYTICAL BIOCHEMISTRY, 1967, 21 (02) : 273 - +
[3] PHENYLALANINE HYDROXYLASE
KAUFMAN, S
[J]. METHODS IN ENZYMOLOGY, 1962, 5 : 809 - 816
[4] INVIVO ENHANCEMENT OF TYROSINE HYDROXYLATION IN RAT STRIATUM BY TETRAHYDROBIOPTERIN
KETTLER, R
BARTHOLINI, G
PLETSCHER, A
[J]. NATURE, 1974, 249 (5456) : 476 - 478
[5] BIOPTERIN DERIVATIVES IN HUMAN-BODY FLUIDS AND TISSUES
LEEMING, RJ
BLAIR, JA
MELIKIAN, V
OGORMAN, DJ
[J]. JOURNAL OF CLINICAL PATHOLOGY, 1976, 29 (05) : 444 - 451
[6] ATP, CYCLIC-AMP, AND MAGNESIUM INCREASE AFFINITY OF RAT STRIATAL TYROSINE-HYDROXYLASE FOR ITS COFACTOR
LOVENBERG, W
BRUCKWICK, EA
HANBAUER, I
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (08) : 2955 - 2958
[7] LOVENBERG W, 1978, PSYCHOPHARMACOLOGY G, P247
[8] DERIVATIZATION AND GAS-CHROMATOGRAPHIC DETERMINATION OF SOME BIOLOGICALLY IMPORTANT ACIDS IN CEREBROSPINAL-FLUID
WATSON, E
WILK, S
[J]. ANALYTICAL BIOCHEMISTRY, 1974, 59 (02) : 441 - 451

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