PEPTIDE-NEUROTRANSMITTER INTERACTIONS INFLUENCING ETHANOL TOLERANCE

被引：14

作者：

HOFFMAN, PL

TABAKOFF, B

机构：

[1] Department of Physiology and Biophysics, University of Illinois Medical Center, Chicago

来源：

DRUG AND ALCOHOL DEPENDENCE | 1979年 / 4卷 / 3-4期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0376-8716(79)90006-1

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Chronic exposure of mice to ethanol leads to the development of functional tolerance to the hypothermic and sedative effects of this drug. Treatment of the animals with the mammalian antidiuretic hormone, arginine vasopressin, results in a prolonged duration of such tolerance, in comparison to animals exposed to ethanol but not to the hormone. Another neurohypophyseal hormone, oxytocin, at an equimolar dose, is ineffective in maintaining tolerance. The centrally mediated effects of arginine vasopressin on memory processes may be related to the hormone-induced prolongation of ethanol tolerance. © 1979.

引用

页码：249 / 253

页数：5

共 26 条

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