OPTIMUM DOSAGE OF AN ORAL-CONTRACEPTIVE - REPORT FROM THE STUDY OF 7 COMBINATIONS OF NORGESTIMATE AND ETHINYL ESTRADIOL

被引：19

作者：

LAWSON, JS

YULIANO, SE

PASQUALE, SA

OSTERMAN, JJ

机构：

[1] ORTHO PHARMACEUT CORP,DEPT MED RES,RARITAN,NJ

[2] ORTHO PHARMACEUT CORP,DIV SCI INFORMATION,RARITAN,NJ

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1979年 / 134卷 / 03期

关键词：

D O I：

10.1016/S0002-9378(16)33039-3

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

A statistically designed study was carried out to determine an optimum combination of norgestimate and ethinyl estradiol as an oral contraceptive, based on efficacy, safety, and side-effect patterns. A total of 1,991 patients were studied for more than two years while they were receiving various dosage combinations of these steroids. There were seven dosage combinations studied as part of a statistically orthogonal experimental design, augmented by three combinations near the center. The data arising from these studies were used to fit approximate functions relating the amount of norgestimate and ethinyl estradiol to the rate of spotting and breakthrough bleeding, gastrointestinal disturbance, and pregnancies. These functions, in turn, helped to identify an optimum dosage (0.125) mg. of norgestimate plus 0.035 mg. of ethinyl estradiol) in the entire range of combinations studied.

引用

页码：315 / 320

页数：6

共 15 条

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