ENHANCEMENT OF INVITRO BINDING AND SOME OF THE PHARMACOLOGICAL PROPERTIES OF DIAZEPAM BY A NOVEL ANTHELMINTIC AGENT, AVERMECTIN-B1A

被引：56

作者：

WILLIAMS, M

YARBROUGH, GG

机构：

[1] Merck Institute for Therapeutic Research, West Point

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 56卷 / 03期

关键词：

!sup]3[!/sup]H-Diazepam binding; Anthelmintic; Diazepam;

D O I：

10.1016/0014-2999(79)90183-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel macrocyclic lactone disaccharide anthelmintic agent, Avermectin B1a (AVM) has been found to cause a concentration-dependent increase in the in vitro binding of 3H-diazepam to rat and mouse brain membranes. The increase in binding is manifested as both an increase in the affinity and number of binding sites for 3H-diazepam. Preliminary in vivo studies demonstrate that AVM can also enhance some of the pharmacological actions of diazepam. © 1979.

引用

页码：273 / 276

页数：4

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