SYNTHESIS OF AN ALPHA-CH2CO2H FUNCTIONALIZED TRYPTOPHAN AND ITS INCORPORATION INTO AN ANALOG OF CHOLECYSTOKININ

被引：17

作者：

BOURNE, GT ^{[1
]}

HORWELL, DC ^{[1
]}

PRITCHARD, MC ^{[1
]}

机构：

[1] ADDENBROOKES HOSP,PARKE DAVIS RES UNIT,HILLS RD,CAMBRIDGE CB2 2QB,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 26期

关键词：

D O I：

10.1016/S0040-4020(01)86480-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of an alpha, alpha-disusbtituted tryptophan derivative (2) predicted by computer assisted molecular modelling to have close structural and conformational analogy to the endogenous neuropeptide cholecystokinin (CCK) is described. Central to the synthesis of (2) is the alkylation of an isonitrile derivative of tryptophan.

引用

页码：4763 / 4774

页数：12

共 17 条

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