PRODUCTION AND CHARACTERIZATION OF MONOCLONAL-ANTIBODIES DIRECTED AGAINST DIFFERENT EPITOPES OF HUMAN THYROID STIMULATING HORMONE

被引：4

作者：

BRAUN, JM ^{[1
]}

CHARREIRE, J ^{[1
]}

机构：

[1] HOP ST LOUIS,SERV CENT MED NUCL,INSERM,U204,F-75475 PARIS 10,FRANCE

来源：

JOURNAL OF IMMUNOLOGICAL METHODS | 1990年 / 132卷 / 02期

关键词：

Anti-thyroid stimulating hormone; Glycoprotein hormone; Monoclonal antibody; Thyroid stimulating hormone; Thyroid stimulating hormone epitope;

D O I：

10.1016/0022-1759(90)90030-Y

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We have produced monoclonal antibodies (mAbs) to human thyroid stimulating hormone (hTSH) and selected five that specifically recognize hTSH and do not cross-react with the other human glycoprotein hormones such as luteinizing hormone (LH), chorionic gonadotropin (CG), follicle stimulating hormone (FSH). All of the antibodies were of the IgG1 subclass with affinities ranging from 5.3 × 108 to 1.9 × 1010 mol-1. 1; they could be assigned to two subgroups on the basis of their epitope specificity. © 1990.

引用

页码：197 / 263

页数：67

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