LEVODOPA TOXICITY IN FETAL-RAT MIDBRAIN NEURONS IN CULTURE - MODULATION BY ASCORBIC-ACID

被引：95

作者：

MENA, MA ^{[1
]}

PARDO, B ^{[1
]}

PAINO, CL ^{[1
]}

DEYEBENES, JG ^{[1
]}

机构：

[1] FDN JIMENEZ DIAZ, SERV NEUROL, MADRID, SPAIN

来源：

NEUROREPORT | 1993年 / 4卷 / 04期

关键词：

LEVODOPA; NEUROTOXICITY; DOPAMINE NEURONS; TRANSPLANTS; ASCORBIC ACID; PARKINSONS DISEASE;

D O I：

10.1097/00001756-199304000-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

LEVODOPA, a dopamine (DA) precursor administered to patients with Parkinson's disease (PD), produces at 25-200 x 10(-6) M concentrations a dose-dependent reduction of H-3-DA uptake in foetal rat midbrain cultures. Also, a decrease in the number of viable cells and tyrosine hydroxylase (TH) positive neurones, plus disruption of the overall neuritic network are observed concurrently with an elevation of quinone levels in the culture medium. Ascorbic acid (AA), which abolished the quinone overproduction, partially prevented these effects. Though levodopa neurotoxicity in vivo is as yet unproven, AA may reduce vulnerability of endogenous or grafted DA neurones in patients with PD.

引用

页码：438 / 440

页数：3

共 25 条

[1] DOES LEVODOPA AGGRAVATE PARKINSONS-DISEASE [J].