THE LEADER PEPTIDE OF THEILERS MURINE ENCEPHALOMYELITIS VIRUS IS A ZINC-BINDING PROTEIN

被引：46

作者：

CHEN, HH

KONG, WP

ROOS, RP

机构：

[1] UNIV CHICAGO,MED CTR,DEPT NEUROL MC2030,CHICAGO,IL 60637

[2] UNIV MICHIGAN,HOWARD HUGHES MED INST,ANN ARBOR,MI 48109

来源：

JOURNAL OF VIROLOGY | 1995年 / 69卷 / 12期

关键词：

D O I：

10.1128/JVI.69.12.8076-8078.1995

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The leader (L) peptide is located in the amino-terminal part of the polyprotein of members of the Cardiovirus (which includes Theiler's murine encephalomyelitis virus) and Aphthovirus genera of picornaviruses. Although the function of L is unknown, strain DA of Theiler's murine encephalomyelitis virus with a mutation of L produces a cell-specific restricted infection. We now report that the DA L peptide is a metalloprotein and that zinc binds to a Cys-His motif that is conserved among cardioviruses.

引用

页码：8076 / 8078

页数：3

共 19 条

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