DESIGN, SYNTHESIS, AND ANTI-TRYPANOSOMA CRUZI EVALUATION OF A NEW CLASS OF CELL-GROWTH INHIBITORS STRUCTURALLY RELATED TO FENOXYCARB

被引：21

作者：

SCHVARTZAPEL, AJ

FICHERA, L

ESTEVA, M

RODRIGUEZ, JB

GROS, EG

机构：

[1] UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM ORGAN,RA-1428 BUENOS AIRES,DF,ARGENTINA

[2] INST NACL INVEST ENFERMEDAD CHAGAS DR M FATALA CH,RA-1063 BUENOS AIRES,DF,ARGENTINA

来源：

HELVETICA CHIMICA ACTA | 1995年 / 78卷 / 05期

关键词：

D O I：

10.1002/hlca.19950780513

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several compounds, structurally related to the insect-growth regulator Fenoxycarb (1), were designed and synthesized. These compounds were tested as growth inhibitors of Trypanosoma cruzi cells (epimastigotes). Compounds 6, 16, 18, and 22 were very active against T.cruzi making them promising good candidates either for blood-bank sterilization or Chagas'-disease surveillance, while compounds 11, 12, 13, and 19 showed a moderate degree of activity.

引用

页码：1207 / 1214

页数：8

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