COMPARATIVE ANTI-INFLAMMATORY AND BONE PROTECTIVE EFFECTS OF 2 DIPHOSPHONATES IN ADJUVANT ARTHRITIS

被引：92

作者：

FLORA, L

机构：

[1] Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio

来源：

ARTHRITIS AND RHEUMATISM | 1979年 / 22卷 / 04期

关键词：

D O I：

10.1002/art.1780220405

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of disodium ethane‐1‐hydroxy‐1,1‐diphosphonate (EHDP) and disodium dichloromethane diphosphonate (Cl2MDP) were evaluated in the rat adjuvant model of arthritis to directly compare their ability to inhibit arthritic processes. The results of the experiment indicated that both diphosphonates inhibited osseous changes, pedal inflammation, and the change in body weight gain patterns which are characteristic of this model. The latter effects suggest that diphosphonates may have antiinflammatory activity that is not related to their previously known actions on bone. Cl2MDP appeared to be more effective than EHDP in this particular model when all aspects were considered. The relationship of these results to the potential safety of these compounds in clinical situations is discussed. Copyright © 1979 American College of Rheumatology

引用

页码：340 / 346

页数：7

共 21 条

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