EFFECTS OF THE ACUTE ADMINISTRATION OF CAFFEINE IN PATIENTS WITH SCHIZOPHRENIA

被引：97

作者：

LUCAS, PB ^{[1
]}

PICKAR, D ^{[1
]}

KELSOE, J ^{[1
]}

RAPAPORT, M ^{[1
]}

PATO, C ^{[1
]}

HOMMER, D ^{[1
]}

机构：

[1] NIMH,CLIN NEUROSCI BRANCH,CLIN STUDIES SECT,NIH BLDG 10,ROOM 4N212,9000 ROCKVILLE PIKE,BETHESDA,MD 20892

来源：

BIOLOGICAL PSYCHIATRY | 1990年 / 28卷 / 01期

关键词：

D O I：

10.1016/0006-3223(90)90429-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Caffeine, 10 mg/kg, was administered to 13 schizophrenic patients in a double-blind placebo-controlled study of its behavioral effects. Some measures of psychopathology were significantly increased: Brief Psychiatric Rating Scale (BPRS) total, BPRS subscales thought disorder, unusual thought content, and euphiria-activation, and several individual BPRS items. Nurses' Bunney-Hamberg ratings of psychosis and mania, comparing the day before with the day after pharmacological challenge, increased significantly. Compared to placebo, caffeine also produced significant increases of diastolic blood pressure and cortisol. Thus, these findings indicate that caffeine increases arousal and has a psychotogenic effect when administered to schizophrenic patients. The possible roles of various neurotransmitters is discussed with special emphasis on caffeine's actions on dopaminergic and adenosinergic systems. © 1990.

引用

页码：35 / 40

页数：6

共 27 条

[1]

ABRAHAM GE, 1972, ANAL LETT, V5, P757

[2]

ACHOR MB, 1981, AM J PSYCHIAT, V138, P392

[3] ADAPTATION OF BLOOD-PRESSURE TO CONTINUOUS HEAVY COFFEE-DRINKING IN YOUNG VOLUNTEERS - A DOUBLE-BLIND CROSSOVER STUDY [J].