SERUM T4, T3 AND REVERSE T3 IN ETHANOL FED RATS

被引：15

作者：

SINGH, SP

PATEL, DG

KABIR, M

PREMACHANDRA, BN

机构：

[1] VET ADM HOSP,ST LOUIS,MO 63125

[2] ST LOUIS UNIV,SCH MED,ST LOUIS,MO 63103

来源：

LIFE SCIENCES | 1979年 / 25卷 / 10期

关键词：

D O I：

10.1016/0024-3205(79)90548-4

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To investigate the influence of chronic ethanol consumption on circulating thyroid hormone levels, male and female rats were given 20% ethanol as the only drinking solution daily for 8 weeks. Blood ethanol levels ranged 30-45 mg/L. In male rats serum T4 decreased from the initial mean ± SD value of 5.2±1.4 to3.0 ±0.7 μg/dl; T3 decreased from initial value of 97±14 to 66±11 ng/dl and rT3 decreased from initial value of 19±9 to 10±1 ng/dl after 8 weeks of ethanol ingestion. Under similar experimental conditions, female rats showed a significant decrease in serum T4 and rT3 levels; however, T3 levels decreased slightly but not significantly as compared to initial values. The results indicate adverse effect of chronic ethanol intake on serum thyroid hormone levels in rats. © 1979.

引用

页码：889 / 894

页数：6

共 26 条

[1] METABOLIC ALTERATIONS PRODUCED IN LIVER BY CHRONIC ETHANOL ADMINISTRATION - CHANGES RELATED TO ENERGETIC PARAMETERS OF CELL [J].